Humane Endpoints resource list

Owiny

Books

• Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation. OECD Environmental Health and Safety Publications Series on Testing and Assessment. No. 19. Paris, November 2000. http://www.oecd.org/ehs/
• Hendriksen   CFM , Morton DB (ed), Humane Endpoints in Animal Experiments for Biomedical Research. Proceedings of the International Conference, 22-25   November 1998. Zeist, The Netherlands.   The Royal Society of Medicine Press, London
• National Research Council, Guide for the care and use of laboratory Animals, 1996, National Academy Press, Washington DC
• Webster's New College Dictionary II, 1995, Houghton Mifflin Company Boston, New York

Journal Articles

• Advanced Physiological Monitoring in Rodents, 2002, ILAR Journal , vol.43(3)
• Bioethics of Laboratory Animal Research,1999,   ILAR Journal, vol 40(1)
• Experimental Design and Statistics in Biomedical Research, 2002, ILAR Journal, vol. 43(4)
• Humane Endpoints for Animals Used in Biomedical Research and Testing,   ILAR Journal, 2000, vol. 41(2)
• Huwer H, Winning J, Vollmar B, Welter C, Menger MD, Schafers HJ, Model of chronic systolic and diastolic dysfunction after cryothermia-induced myocardial necrosis in rats, Comparative Medicine 2000, vol.50, page 385-390

abstract

• Impact of Noninvasive Technology on Animal Research, 2001, ILAR Journal, 2001, vol. 42(3)
• Krarup A, Chattopadhyay P, Bhattacharjee AK, Burge JR, Ruble GR, Evaluation of surrogate markers of impending death in the galactosamine-sensitized murine model of bacterial endotoxemia Laboratory Animal Science, 1999, vol. 49, page 545-550.

abstract

• Louie A, Liu W, Liu QF, Sucke AC, Miller DA, Battles A, Miller MH, Predictive value of several signs of infection as surrogate markers for mortality in a neutropenic guinea pig model of Pseudomonas aeruginosa sepsis. Laboratory Animal Science, 1997, vol. 47 (6), page 617-623

abstract

• Morton DB, Clinical Scores to promote continuity of good care, ILAR Journal, 2000, vol.41, page 80-86
• Shih IM, Torrance C, Sokoll LJ, Chan DW, Kinzler KW, Vogelstein B, Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin, Nature Medicine. Jun 2000, 6(6), page 711-4

article

• Ullman-Cullere MH, Foltz CJ, Body Condition Scoring: A Rapid and Accurate Method for Assessing Health Status in Mice,. Laboratory Animal Science ,vol. 49(3), June 1999, page 319-323
• Vlach KD, Boles JW, Stiles BG., Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock, Comparative Medicine, 2000, vol.50, page160-166

abstract

Internet

• http://altweb.jhsph.edu/
• http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm
• http://altweb.jhsph.edu/topics/humane-endpoints.htm

• http://www.hopkinsmedicine.org/comparativemedicine/
• http://www.jhu.edu/animalcare/
• http://www.jhu.edu/animalcare/committee1.html
• http://www.oecd.org.ehs
• http://www.vetmed.ucdavis.edu/Animal_Alternatives/main.htm

Additional resources

Books

• CCAC guidelines on: choosing an appropriate endpoint in experiments using animals for research, teaching and testing, 1998

http://www.ccac.ca/english/gui_pol/gdlines/endpts/APPOPEN.HTM

Journal Articles

• Dragunsky E, Nomura T, Karpinski K, Furesz J, Wood DJ, Pervikov Y, Abe S, Kurata T, Vanloocke O, Karganova G, Taffs R, Heath A, Ivshina A, Levenbook I, Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study, Bulletin of the World Health Organisation, May 16 2003, vol. 81(4), page 251-260

Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study

• Hawkins P, Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations, Laboratory Animals, October 2002, vol.36(4), page 378-395

Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations

• Jegstrup I, Thon R, Hansen AK, Hoitinga MR, Characterization of transgenic mice--a comparison of protocols for welfare evaluation and phenotype characterization of mice with a
• suggestion on a future certificate of instruction, Laboratory Animals, January 2003, vol. 37(1), page1-9

Characterization of transgenic mice--a comparison of protocols for welfare evaluation and phenotype characterization of mice with a suggestion on a future certificate of instruction

• Kramer K, Kinter LB, Evaluation and applications of radiotelemetry in small laboratory animals, Physiol Genomics, May 2003,vol. 13(3), page 197-205
• Wright AJ, Phillpotts RJ, Humane endpoints are an objective measure of morbidity in Venezuelan encephalomyelitis virus infection of mice, Archives of Virology, 1998,vol. 143(6), page1155-1162

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