In Vitro and Other Replacement Approaches
Alan M. Goldberg Ph.D.,/ James Yager Ph.D., Johns Hopkins University,
Bloomberg School of Public Health

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Opening Remarks

Replacement

Reduction and Refinement

Concept of Replacement Alternatives

Organizations for Validation of Alternative Methods

Systems for Testing

Physiologically Based Pharmacokinetic (PBPK) Modeling

Insulin / Anti-Cancer Agent Screening

The Use of Reconstituted Tissue Equivalents

Advantages / Disadvantages of In Vitro Systems

Conclusions

Study Questions

Resources (reference articles/books)